Dr. Neo Cortex

Doctor Neo Periwinkle Cortex  (often referred to as Doctor Cortex, or simply Cortex) is a video game character and the primary antagonist of the Crash Bandicoot series. His name is a play on the term neocortex, an area of the brain. In the series, Cortex is depicted as a mad scientist who seeks to achieve world domination as an act of vengeance for the ridicule he has suffered in the past. Hoping to achieve this by mutating the local animals into his soldiers, he eventually creates Crash Bandicoot, the titular character of the series, but soon rejects him as unworthy of being in his army and removes him from his castle. As Cortex's actions endanger the sanctity of the islands the games are set in, Cortex's plans for world domination are often hampered by Crash along with other characters. Crash's constant interference has made eliminating Crash one of Cortex's top priorities along with world domination.
Cortex was created by Andy Gavin and Jason Rubin, and was originally designed by Charles Zembillas. Critical reception of Cortex has been mostly positive, with much of the praise going to his portrayal in Crash Twinsanity. The character's reception before and after the game, however, has been mixed.

The idea for Cortex was conceived while Andy Gavin, Jason Rubin, Dave Baggett and Mark Cerny were eating "mediocre Italian" near Universal Interactive Studios. Gavin came up with the idea of an "evil genius villain with a big head" who was "all about his attitude and his minions". Rubin, having become fond of the animated television series Pinky and the Brain, imagined a "more manevolent Brain" with minions resembling the weasel characters in Who Framed Roger Rabbit. After Gavin performed a "silly villain voice" depicting the attitude in mind for the character, the villain's name, Doctor Neo Cortex, was instantly formulated. Gavin and Rubin described Cortex to character designer Charles Zembillas as "[having] a huge head but a tiny body, he’s a mad scientist, and he dresses a bit like a Nazi from the Jetsons" Jason Rubin owns the original sketches of Cortex by Zembillas. Because Cortex's game model was unable to walk properly due to the short length of his legs, the character was kept stationary in much of his appearances. Cortex is voiced by Brendan O'Brien in the first Crash Bandicoot game, by Clancy Brown from Crash Bandicoot 2: Cortex Strikes Back up to Crash Nitro Kart and by Lex Lang from Crash Twinsanity onwards.In the Japanese versions of the games, he is voiced by Shōzō Iizuka up to Crash Tag Team Racing and by Yōsuke Akimoto in Crash Boom Bang!. In a flashback to Cortex's childhood in Crash Twinsanity, he is voiced by Debi Derryberry in the English version of the game and by Noriko Suzuki in the Japanese version.
Cortex's main motivation for conquering the world stems from extensive ridicule he had suffered in the past. He is also talked into world domination plots by his overseer Uka Uka, whom Cortex formerly feared to the point that he got down on his hands and knees in his presence. Overtime, this fear of Uka Uka would disappear, leading to Cortex opposing his own replacement in Crash of the Titans and eventually revolting against him in Crash: Mind over Mutant, citing a desire to "run this operation [...] again" as justification for his actions. Cortex has been described as having an ego "the size of a hot air balloon". His egomania often blinds him to others' hatred of him to the point where he delusively believes that he is in fact loved by everyone, including those he considers his enemies.While he frequently declares himself to be aesthetically attractive, he has displayed self-conscious behavior about his physical appearance on at least one occasion. In addition, he dislikes personal habits that he deems disgusting, and once went as far as placing a bounty on someone who ate sandwiches while going to the bathroom.
Cortex was once described as having a "huge head and bright yellow skin" by a minor character in Crash Tag Team Racing. His most distinguishing feature is the large N located on his forehead, the origin of which is unknown. However, in the back of the Prima Strategy Guide for Crash Team Racing, it states that the N was tattooed on his head by his childhood bullies. The N stands for nerd. Cortex is near-bald with the exception of a few areas on his head; Andy Gavin and Jason Rubin humorously explained that Cortex only uses Rogaine on those select areas. The hair that he does have is black (blue in recent installments) and frazzled. In much of his appearances, Cortex is dressed in a white lab coat, black underclothes and matching gloves and boots (yellow in earlier games and reddish-brown in later appearances). Cortex stands 1.6 meters (about five feet and three inches) and weighs 59 kilograms (130 pounds).


^{Source: http://en.wikipedia.org/wiki/Doctor_Neo_Cortex}